반응 #55937

반응 방정식

magnesium

benzene

3-bromopentane

magnesium

3-pentyl magnesium bromide

sulfuric acid

3-bromopentane

methyltin trichloride

→

yellow liquid

수율 85.0%

Methyl Tri(3-pentyl)tin

수율 85.0%

용매

water

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.ADDITIONwas added a 25 cc
2. 2
   workup.ADDITIONportion of a solution containing 99.7 g
3. 3
   온도was heated to the boiling point
4. 4
   온도Heating
5. 5
   workup.WAITwas continued for an additional hour
6. 6
   기타to have reacted
7. 7
   workup.DISSOLUTIONdissolved in 50 cc
8. 8
   workup.ADDITIONThe addition required 0.5 hour
9. 9
   workup.ADDITIONDuring the addition the temperature of the reaction mixture
10. 10
    기타rose to 71° C
11. 11
    workup.ADDITIONcompletion of the addition the reaction mixture
12. 12
    온도was heated to the boiling point for one hour
13. 13
    workup.ADDITIONcontaining 250 cc
14. 14
    기타The aqueous phase was separated
15. 15
    기타the residual was removed
16. 16
    기타was subsequently removed by filtration
17. 17
    기타The solvent was evaporated under reduced pressure
18. 18
    기타to yield 58.8 g

실험 절차

To 16 g. (0.66 g. atom) of magnesium turnings maintained at a temperature of 25° C. under a nitrogen atmosphere was added a 25 cc. portion of a solution containing 99.7 g. (0.66 mole) of 3-bromopentane dissolved in 300 cc. of anhydrous tetrahydrofuran. The reaction was initiated using a few drops of ethylene dibromide. The remaining portion of the 3-bromopentane solution was gradually added during a period of one hour while the reaction mixture was heated to the boiling point. Heating was continued for an additional hour. The reaction mixture was then allowed to cool to ambient temperature, at which time all of the magnesium appeared to have reacted. The resultant solution contained 0.6 mole of 3-pentyl magnesium bromide, and was added dropwise to a stirred solution of methyltin trichloride (49 g., 0.2 mole) dissolved in 50 cc. of dry benzene. The addition required 0.5 hour and was conducted under a nitrogen atmosphere. During the addition the temperature of the reaction mixture rose to 71° C. Following completion of the addition the reaction mixture was heated to the boiling point for one hour, then allowed to cool to ambient temperature. To the resultant mixture was added a solution containing 250 cc. water and 15 cc. concentrated sulfuric acid over a five minute period. The aqueous phase was separated and the residual was removed by combining the organic phase with a portion of anhydrous magnesium sulfate, which was subsequently removed by filtration. The solvent was evaporated under reduced pressure to yield 58.8 g. (85% yield) of a yellow liquid exhibiting a refractive index (nD25) of 1.4954. This product was extracted twice with methanol and distilled under reduced pressure. The fraction boiling from 81° to 87° C. under a pressure of 0.15 mm. was isolated and exhibited a refractive index (nD22) of 1.4920. Analysis by vapor phase chromatography indicated that the product was 95.7% pure.

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