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4-Hydroxy-3-(2-hydroxy-1,1-dimethylethyl)phenyl methanesulphonate

4-hydroxy-3-(2-hydroxy-1,1-dimethylethyl)phenyl methanesulphonate

trimethyl orthoformate

p-toluenesulphonic acid

→

4,5-dihydro-2-methoxy-5,5-dimethyl-1,3-benzodioxepin-7-yl methanesulphonate

수율 79.0%

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실험 절차

4-Hydroxy-3-(2-hydroxy-1,1-dimethylethyl)phenyl methanesulphonate (10.4 parts) (from Example 1) was reacted with trimethyl orthoformate (127 parts) in the presence of p-toluenesulphonic acid (0.05 parts) as in Example 20 to produce 4,5-dihydro-2-methoxy-5,5-dimethyl-1,3-benzodioxepin-7-yl methanesulphonate (9.5 parts, 79% yield) as a colourless oil.

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