반응 #5591

반응 방정식

2,6-bis(1,1-dimethylethyl)-4-mercaptophenol

title compound

N-tricyclo[3.3.1.13,7 ]dec-1-yl-2-propenamide

triethylamine

→

3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-N-tricyclo[3.3.1.13,7 ]dec-1-ylpropanamide

용매

methanol

반응 조건

후처리

1. 1
   기타The solvent and triethylamine were removed on a rotary evaporator
2. 2
   기타the product purified by chromatography on silica
3. 3
   기타recrystallized from ethyl aceate/hexane
4. 4
   여과filtered
5. 5
   기타dried in vacuo, m.p. ca
6. 6
   기타172.5°-173.5° C.

실험 절차

Following the method of Example 4, 2,6-bis(1,1-dimethylethyl)-4-mercaptophenol (1.19 g, 0.005 mole), the title compound of Example 5 (1.03 g, 0.005 mole) and triethylamine (0.5 ml) were stirred in methanol (100 ml) for 12 hours at room temperature under argon. The solvent and triethylamine were removed on a rotary evaporator and the product purified by chromatography on silica, recrystallized from ethyl aceate/hexane, filtered and dried in vacuo, m.p. ca.172.5°-173.5° C.

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