반응 #55869

반응 방정식

Thiophene

trichloroacetaldehyde

→

α-trichloromethyl-2-thiophenemethanol

수율 20.0%

용매

n-heptane

반응 조건

후처리

1. 1
   온도The solution was heated
2. 2
   온도under reflux for 3.5 hr
3. 3
   온도After cooling
4. 4
   농축the n-heptane solution was concentrated
5. 5
   workup.DISTILLATIONthe residue was purified by distillation

실험 절차

Thiophene (4.2 g, 50 mmol) and trichloroacetaldehyde (7.35 g, 50 mmol) were dissolved in n-heptane (25 ml). The solution was heated under reflux for 3.5 hr. under a Soxleht apparatus in which Amberlyst 15 (4.2 g) had been placed. After cooling, the n-heptane solution was concentrated, and the residue was purified by distillation to give 2.32 g of α-trichloromethyl-2-thiophenemethanol boiling at 98°-100° C./1.0 mmHg.

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