반응 #558591

ord-2b290610429e41178b29adb766c1dbf6

반응 방정식

CCc1nc(N)ccc1C#C[Si](C)(C)C
6-ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine
O=C([O-])[O-].[K+].[K+]
K2CO3
→
C#Cc1ccc(N)nc1CC
title compound
C#Cc1ccc(N)nc1CC
6-Ethyl-5-ethynyl-pyridin-2-ylamine

반응물

CCc1nc(N)ccc1C#C[Si](C)(C)C
6-ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine
O=C([O-])[O-].[K+].[K+]
K2CO3

시약

없음

용매

CO
MeOH

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타The product is purified by chromatography on silica gel using a DCM/MeOH gradient

실험 절차

The title compound is synthesized according to general procedure GP3 starting from 12.23 g (56 mmol) 6-ethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 3.87 g (28 mmol) K2CO3 in 120 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 4.5 g (85%).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08633183B2uspto-grants-2014_01