반응 #558587

반응 방정식

6-trifluoromethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine

K2CO3

→

title compound

5-Ethynyl-6-trifluoromethyl-pyridin-2-ylamine

용매

MeOH

반응 조건

후처리

1. 1
   기타The product is purified by chromatography on silica gel using a cyclohexane/ethyl acetate gradient

실험 절차

The title compound is synthesized according to general procedure GP3 starting from 2.82 g (11.0 mmol) 6-trifluoromethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 757 mg (5.5 mmol) K2CO3 in 25 mL MeOH. The product is purified by chromatography on silica gel using a cyclohexane/ethyl acetate gradient. Yield: 0.9 g (44%).

출처