반응 #558571

반응 방정식

4-hydroxy-5-iodo-6-ethyl pyrimidine

POCl3

→

desired product

4-Chloro-5-iodo-6-ethyl-pyrimidin

반응 조건

후처리

1. 1
   농축The reaction mixture is concentrated under reduced pressure
2. 2
   workup.ADDITIONthe residue is poured
3. 3
   기타into crushed ice
4. 4
   여과The precipitated solid is collected by filtration
5. 5
   세척washed with water
6. 6
   기타After drying

실험 절차

A suspension of 90 g (0.36 mol) 4-hydroxy-5-iodo-6-ethyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90° C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (65 g; 67%).

출처