반응 #5585

반응 방정식

ethanol

sodium mercaptoethansulphonate

mercaptoethansulphonic acid

arginine

→

white crystalline product

수율 98.0%

arginine mercaptoethansulphonate

수율 98.0%

용매

water

반응 조건

후처리

1. 1
   농축The solution is then concentrated to dryness
2. 2
   기타giving a residue which
3. 3
   workup.STIRRINGThe suspension is agitated at 50° C. for 30 minutes
4. 4
   온도cooled
5. 5
   여과filtered

실험 절차

12 g of sodium mercaptoethansulphonate are freed in aqueous solution and under nitrogen stream in a column, as described in the example 1. The mercaptoethansulphonic acid coming out of the column in aqueous solution, under nitrogen stream and at pH=1, is gradually added with arginine, in free base form, in stoichiometrical amount dissolved in water under nitrogen stream (12.7 g), by operating at pH values of between 6 and 7. Upon the salification is completed the pH of the solution of the salt must be of between 6 and 7. The solution is then concentrated to dryness giving a residue which, upon being taken with 200 ml of absolute ethanol, under stirring and in hot condition, is converted into white crystals. The suspension is agitated at 50° C. for 30 minutes, then cooled and filtered, whereby 22.8 g of white crystalline product are obtained, with a 98% yield and a melting point of 214°-216° C.; the pH in 10% aqueous solution is 6.7 and the solubility in water is perfect. The analysis gave the following results:

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