반응 #55828

ord-c0b4079ea0374705a17d25381f895c0e

반응 방정식

COC(=O)c1ncoc1Cc1ccccc1
Methyl 5-benzyl-4-oxazolecarboxylate
[Al+3].[H-].[H-].[H-].[H-].[Li+]
lithium aluminium hydride
→
OCc1ncoc1Cc1ccccc1
5-benzyl-4-hydroxymethyloxazole

반응물

COC(=O)c1ncoc1Cc1ccccc1
Methyl 5-benzyl-4-oxazolecarboxylate
[Al+3].[H-].[H-].[H-].[H-].[Li+]
lithium aluminium hydride

시약

없음

용매

C1CCOC1
tetrahydrofuran

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Methyl 5-benzyl-4-oxazolecarboxylate is reduced with lithium aluminium hydride in tetrahydrofuran to give 5-benzyl-4-hydroxymethyloxazole, which by reacting with thionyl chloride is converted to 5-benzyl-4-chloromethyloxazole.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04221802uspto-grants-1980_09