반응 #5580

반응 방정식

5-[2-(isopropyloxycarbonylamino)ethylthio]imidazo[1,2-a]pyridine

N-bromosuccinimide

→

desired product

수율 82.7%

3-bromo-5-[2-(isopropyloxycarbonylamino)ethylthio]imidazo[1,2-a]pyridine

수율 82.7%

용매

chloroform

반응 조건

후처리

1. 1
   세척The reaction solution was washed with water
2. 2
   건조dried over anhydrous magnesium sulfate
3. 3
   workup.DISTILLATIONAfter the solvent was distilled off
4. 4
   기타the residue was purified by column chromatography (eluent: ethyl acetate)

실험 절차

To a solution of 5-[2-(isopropyloxycarbonylamino)ethylthio]imidazo[1,2-a]pyridine (279 mg, 1 mmole) in chloroform (5 ml) was added N-bromosuccinimide (187 ml, 1.05 mmoles) and the mixture was stirred at room temperature for 1 hour. The reaction solution was washed with water and dried over anhydrous magnesium sulfate. After the solvent was distilled off, the residue was purified by column chromatography (eluent: ethyl acetate) to obtain 296 mg of the desired product (82.7%, colorless solid).

출처