반응 #55799

반응 방정식

2-chloromethylpyrimidine

ethylenediamine

N-(2-pyrimidylmethyl)ethylenediamine

methyl isothiocyanate

→

title compound

N-Cyano-N'-methyl-N"-[2-(2-pyrimidylmethylamino)ethyl]-guanidine

반응 조건

후처리

1. 1
   기타gives
2. 2
   농축after concentrating
3. 3
   기타This thiourea is reacted with lead cyanamide by the procedure of Examples 3(b)

실험 절차

Reaction of 2-chloromethylpyrimidine with ethylenediamine by the procedure of Example 34 and reaction of the resulting N-(2-pyrimidylmethyl)ethylenediamine with methyl isothiocyanate by the procedure of Example 3(b) gives, after concentrating and chromatographing, N-methyl-N'-[2-(2-pyrimidylmethylamino)ethyl]thiourea. This thiourea is reacted with lead cyanamide by the procedure of Examples 3(b) to give the title compound.

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