반응 #55754

반응 방정식

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

hydrogen bromide

→

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide

용매

acetic acid

반응 조건

후처리

1. 1
   온도under reflux for 7 hours
2. 2
   온도Cooling

실험 절차

A mixture of 4-hydroxymethyl-5-methylimidazole hydrochloride (15.0 g.), cysteamine hydrochloride (11.5 g.) and a solution of hydrogen bromide in acetic acid (48%, 225 ml.) was heated under reflux for 7 hours. Cooling afforded 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide (21.6 g.), m.p. 208°-211°.

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