반응 #55753

반응 방정식

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

→

4-methyl-5-[(2-aminoethyl)thiomethyl]-imidazole dihydrochloride

수율 164.7%

용매

isopropyl alcohol

hydrochloric acid

반응 조건

후처리

1. 1
   온도under reflux for 17 hours
2. 2
   농축Concentration
3. 3
   기타followed by re-evaporation with water
4. 4
   기타afforded a residue which
5. 5
   농축concentrated to low bulk
6. 6
   온도cooled

실험 절차

A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in concentrated aqueous hydrochloric acid (450 ml.) was heated under reflux for 17 hours. Concentration followed by re-evaporation with water afforded a residue which was dissolved in isopropyl alcohol, concentrated to low bulk and cooled to afford 4-methyl-5-[(2-aminoethyl)thiomethyl]-imidazole dihydrochloride (40.6 g.), m.p. 185°-191°.

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