반응 #55741
ord-9ea65976033349a791ade5e6d989ca8d
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1workup.STIRRINGStirring
- 2여과filtered
- 3여과After filtration with suction
- 4기타the product was recrystallized from ethanol
실험 절차
10 g of 4-(2-aminoethyl)-benzoic acid hydrochloride were dissolved in 60 ml of 2 N-sodium hydroxide solution and, after addition of 75 ml of acetone, a solution of 11 g of 2-ethoxy-5-chloro-benzoylchloride in 20 ml of acetone was added dropwise, while stirring. Stirring was continued for 2 hours, the mixture was diluted with water, filtered and acidified with dilute hydrochloric acid. After filtration with suction, the product was recrystallized from ethanol. The 4-(2-<2-ethoxy-5-chloro-benzamido>-ethyl)-benzoic acid obtained was found to melt at 180° C.