반응 #557339

반응 방정식

1-(2-Cyano-acetyl)-3-phenyl-urea

→

solids

수율 94.4%

6-Amino-1-phenyl-1H-pyrimidine-2,4-dione

수율 94.4%

용매

sodium hydroxide

반응 조건

후처리

1. 1
   온도After cooling down
2. 2
   기타neutralization with acetic acid and thus formed solids were separated by filtration
3. 3
   세척washed well with ice cold water
4. 4
   기타dried under high vacuum

실험 절차

1-(2-Cyano-acetyl)-3-phenyl-urea (12.6 g, 62.1 mmol) was taken in 50 ml 2M sodium hydroxide (aq.) and stirred at room temperature for 2 h under LC-MS control. After cooling down by immersing in ice bath and neutralization with acetic acid and thus formed solids were separated by filtration, washed well with ice cold water and dried under high vacuum yielding white solids (11.9 g, 58.6 mmol, 94.4%).

출처