반응 #55721

반응 방정식

9-(1-Hydroxy-2-propyl)-6-chloropurine

hydroiodic acid

→

9-(1-HYDROXYL-2-PROPYL)-6-IODOPURINE

용매

H2O

반응 조건

후처리

1. 1
   여과The precipitate was filtered
2. 2
   기타neutralized with anhydrous sodium acetate at 5°
3. 3
   세척washed with a little cold water (3 times)
4. 4
   기타Recrystallization from ethanol/H2O
5. 5
   기타gave colorless crystals

실험 절차

9-(1-Hydroxy-2-propyl)-6-chloropurine (I, 1.5 g, 7 mmol) was added to hydroiodic acid (15 ml) at -10° with stirring for 45 min. The precipitate was filtered, neutralized with anhydrous sodium acetate at 5°, and washed with a little cold water (3 times). Recrystallization from ethanol/H2O, gave colorless crystals. Yield=0.9 g (42%) mp=193°-194° uv λmax 276 nm (H2O, pH 5.5).

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