반응 #55704

반응 방정식

4-chlorobenzyl cyanide

caprolactim methyl ether

diazabicyclo [5.4.0]undec-5-ene

→

title compound

수율 67.6%

2-(α-cyano-4-chlorobenzylidene)perhydroazepine

수율 67.6%

용매

methyl alcohol

반응 조건

후처리

1. 1
   온도Cool
2. 2
   기타the thus-obtained reaction mixture to ambient temperature
3. 3
   여과before filtering

실험 절차

Agitate a mixture of 5.0 g of 4-chlorobenzyl cyanide, 5.5 g of caprolactim methyl ether and 0.5 g of diazabicyclo [5.4.0]undec-5-ene under nitrogen for 18 hours at 125°. Cool the thus-obtained reaction mixture to ambient temperature and then rub down the crystallizing residue with 20 ml of methyl alcohol before filtering to obtain 5.5 g of the title compound. Recrystallize this compound from methyl alcohol to obtain a product with a MP of 114° to 117°.

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