반응 #556452

반응 방정식

Mannitol

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid monosodium salt

sodium hydroxide

→

mannitol

title compound

N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt

용매

water

반응 조건

후처리

1. 1
   workup.DISSOLUTIONdissolved
2. 2
   여과The solution is then filtered through
3. 3
   여과a bacterial filter
4. 4
   기타dried in a freeze-drier

실험 절차

5 grams of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid monosodium salt (purity 99.7% by HPLC) are dissolved in 1 L of distilled water and 5.563 ml of a 2.0 M solution of sodium hydroxide is added to the solution. Mannitol (10 g) is then added to the solution and dissolved. The solution is then filtered through a bacterial filter and dried in a freeze-drier to afford the title compound as a white solid in mixture with mannitol (15.2 g, purity 99.7% area by HPLC).

출처