반응 #55619

반응 방정식

3-isopropyl-3-methyl-5H-imidazo[2,1-a]isoindole-2(3H),5-dione

dimethylamine

→

o-(5-isopropyl-5-methyl-4-oxo-2-imidazolin-2-yl)-N,N-dimethylbenzamide

수율 91.3%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   기타The bottle is sealed
2. 2
   온도The mixture is cooled
3. 3
   기타the contents of the bottle transferred to a flask
4. 4
   기타The solvent is then removed in vacuo
5. 5
   여과filtered
6. 6
   세척washed with ether

실험 절차

To a cold solution of 180 g of 3-isopropyl-3-methyl-5H-imidazo[2,1-a]isoindole-2(3H),5-dione in 300 ml of dry tetrahydrofuran in a pressure bottle is added 68 g of dimethylamine. The bottle is sealed and the mixture heated to 50° C. with stirring for 16 hours. The mixture is cooled, and the contents of the bottle transferred to a flask. The solvent is then removed in vacuo. The crystalline residue is then suspended in ether, filtered, washed with ether, and airdried to give 195 g of o-(5-isopropyl-5-methyl-4-oxo-2-imidazolin-2-yl)-N,N-dimethylbenzamide, melting point 144°-146° C. This product is recrystallized from acetonitrile to give an analytically pure product, melting point 147°-150° C.

출처