반응 #55616

반응 방정식

N-chloroacetyl-2,6-dimethylaniline

3-methyl-5-chloromethylisoxazole

sodium hydride

→

pure product

수율 30.0%

2-chloro-N-(3-methylisoxazol-5-yl)methyl-N-(2,6-dimethylphenyl)acetamide

수율 30.0%

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타After workup, the solid product was purified by column and high-pressure liquid chromatography

실험 절차

A mixture of 4.54 g N-chloroacetyl-2,6-dimethylaniline and 3 g 3-methyl-5-chloromethylisoxazole (prepared as in Example 8 above) in 100 ml dry dimethylformamide was treated with 1.33 g sodium hydride as in Example 3 above. After workup, the solid product was purified by column and high-pressure liquid chromatography to yield 2.0 g pure product, m.p. 78°-82° C. This product is shown as Compound 1 in Table I. C15H17ClN2O2 : calc., %C 61.54, %H 5.81, %N 9.57; found, %C, 63.37, %H 6.16, %N 9.65.

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