반응 #55591

반응 방정식

Cyclobutane carbinol

tosyl chloride

HCl

→

title compound

수율 105.8%

(p-Toluenesulfonyloxy) (cyclobutyl) methane

수율 105.8%

용매

pyridine

반응 조건

후처리

1. 1
   기타The layers were separated
2. 2
   추출the aqueous layer extracted with ether-ethyl acetate
3. 3
   세척The combined extracts were washed with 10% aqueous sodium bicarbonate (NaHCO3)
4. 4
   건조dried (MgSO4)
5. 5
   여과filtered
6. 6
   기타evaporated in vacuo

실험 절차

A solution of 24.4 g of Cyclobutane carbinol (prepared in Example 42A) in 570 ml of dry pyridine was stirred under argon at -10° C. and 81.0 g of tosyl chloride added in small portions. The reaction mixture was stirred at -10° C. to -0° C. for 4.5 hr, then poured into 1 liter of chilled 6 N HCl. The layers were separated and the aqueous layer extracted with ether-ethyl acetate. The combined extracts were washed with 10% aqueous sodium bicarbonate (NaHCO3), dried (MgSO4), filtered and evaporated in vacuo to yield 72.0 g of the title compound having the following physical characteristics:

출처