반응 #55566

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9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid, methyl ester

NaOH

→

9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid

수율 91.5%

용매

water

methanol

water

반응 조건

후처리

1. 1
   추출extracted with diethyl ether (10 ml)
2. 2
   추출extracted with diethyl ether (3×15 ml)
3. 3
   세척The ethereal solution is washed with water to neutrality
4. 4
   건조dried over sodium sulphate
5. 5
   기타the solvent evaporated in vacuo

실험 절차

The solution of 0.5 g of 9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid, methyl ester, 0.170 g of NaOH in water (1.5 ml), methanol (4.5 ml) is left for two hours at room temperature under nitrogen, then diluted with water (22 ml) and extracted with diethyl ether (10 ml). The aqueous layer is acidified (congo red) with HCl (5%), then extracted with diethyl ether (3×15 ml). The ethereal solution is washed with water to neutrality, dried over sodium sulphate and the solvent evaporated in vacuo to yield 0.44 g of 9-keto-15-hydroxy-19-methyl-prosta-13,18-dienoic acid (oil).

출처