반응 #55563

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9-ethylenedioxy-15-keto-19-methyl-prost-13,18-dienoic acid, methyl ester

→

9-ethylenedioxy-15-keto-19-methyl-prost-18-enoic acid, methyl ester

수율 88.2%

용매

ethanol

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후처리

1. 1
   세척washed with ethanol
2. 2
   기타is hydrogenated at room temperature under pressure
3. 3
   기타After absorption of the theoretical quantity of hydrogen the catalyzer
4. 4
   기타is separated by filtration
5. 5
   기타the solvent evaporated in vacuo

실험 절차

To the solution of 4.4 g of 9-ethylenedioxy-15-keto-19-methyl-prost-13,18-dienoic acid, methyl ester, in ethanol (60 ml.) are added 0.8 g of Raney-nickel washed with ethanol and the mixture is hydrogenated at room temperature under pressure. After absorption of the theoretical quantity of hydrogen the catalyzer is separated by filtration and the solvent evaporated in vacuo, to yield 3.9 g of 9-ethylenedioxy-15-keto-19-methyl-prost-18-enoic acid, methyl ester.

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