반응 #55556

반응 방정식

hydrochloric acid

7-[2-(2-formamidothiazol-4-yl)-2-methoxyiminoacetamido]-3-(5-t-butoxycarbonylaminomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid

→

7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(5-aminomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid dihydrochloride

수율 83.8%

용매

methanol

반응 조건

후처리

1. 1
   기타After evaporation of the solvent under reduced pressure, methanol
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   기타evaporated again
4. 4
   세척The residue was washed with diethyl ether
5. 5
   기타dried

실험 절차

Conc.hydrochloric acid (1.82 g) was added to a suspension of 7-[2-(2-formamidothiazol-4-yl)-2-methoxyiminoacetamido]-3-(5-t-butoxycarbonylaminomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid (syn isomer, 3.9 g) in methanol (60 ml), and the mixture was stirred at room temperature for 2 hrs. After evaporation of the solvent under reduced pressure, methanol was added to the residue and evaporated again. The residue was washed with diethyl ether and dried to give 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(5-aminomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acid dihydrochloride (syn isomer, 3.0 g).

출처