반응 #55500
ord-32cef9d776e644fa9ed2f82788d54e0e
반응 조건
온도
-15°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타the organic phase is separated
- 2세척washed with two 100 ml portions of water
- 3건조dried over sodium sulphate
- 4기타The solvent is evaporated
실험 절차
A suspension of 369 g of cyanuric chloride in 1000 ml of ethyl acetate is cooled to -15° C. With good stirring, 124 g of isopropylamine are first added dropwise at -20° C. to -10° C. in the course of 21/2 hours, followed by 267 g of a 30% aqueous solution of sodium hydroxide in the course of one hour. The reaction mixture is stirred for a further 11/2 hours at the same temperature, then the organic phase is separated, washed with two 100 ml portions of water and dried over sodium sulphate. The solvent is evaporated, to yield an oil from which the 2,4-dichloro-6-isopropylamino-s-triazine precipitates in crystalline form after stirring with petroleum ether at low temperature. Melting point: 46°-47° C.