반응 #55465

반응 방정식

N-(3',4'-dichlorophenyl)-3,4-dimethyl-2-hydroxy-5-oxo-2,5-dihydropyrrole

N-(3',4'-Dichlorophenyl)-3,4-dimethyl-2-hydroxy-5-oxo-2,5-dihydropyrrole

thionyl chloride

→

N-(3',4'-Dichlorophenyl)-3,4-dimethyl-2-chloro-5-oxo-2,5-dihydropyrrole

반응 조건

후처리

1. 1
   농축the mixture is concentrated by evaporation in vacuo
2. 2
   기타The solid residue is triturated with petroleum ether
3. 3
   기타to obtain 27.4 g (95% of theory) of the above compound in the form of light-yellow crystals, m.p. 95°-96°

실험 절차

27.2 g of N-(3',4'-dichlorophenyl)-3,4-dimethyl-2-hydroxy-5-oxo-2,5-dihydropyrrole (see Example 3) is added to 25 ml of thionyl chloride, with an intense evolution of gas occurring. After being stirred for one hour at 50°, the mixture is concentrated by evaporation in vacuo. The solid residue is triturated with petroleum ether to obtain 27.4 g (95% of theory) of the above compound in the form of light-yellow crystals, m.p. 95°-96°.

출처