반응 #55459

반응 방정식

1,2-dimethoxyethane

n-butyl lithium

ethyl mercaptoacetate

ethyl 3-(1-benzyl-5-methyl-4-imidazolyl)-2-propenoate

1,2-dimethoxyethane

→

ethyl 2-[1-benzyl-5-methyl-4-imidazolyl]-4-oxotetrahydrothiophene

용매

hexane

반응 조건

후처리

1. 1
   기타at 10° C
2. 2
   workup.WAITis left at room temperature overnight
3. 3
   온도The reaction mixture is cooled in ice
4. 4
   workup.ADDITIONis diluted with 300 ml
5. 5
   여과of ether and filtered
6. 6
   workup.DISSOLUTIONThe solid is dissolved in 100 ml
7. 7
   추출is extracted with a mixture of chloroform and methylene chloride
8. 8
   건조The combined extracts are dried over anhydrous sodium sulfate
9. 9
   여과filtered
10. 10
    농축concentrated in vacuo

실험 절차

A solution of ethyl mercaptoacetate (7.45 g., 0.062 mole) in 59 ml. of dry 1,2-dimethoxyethane is cooled to 5° C. and n-butyl lithium (41.3 ml., 0.062 mole) in hexane is added dropwise over 1/2 hour under a nitrogen atmosphere. To this solution is added ethyl 3-(1-benzyl-5-methyl-4-imidazolyl)-2-propenoate (13.0 g., 0.0514 mole) in 50 ml. of 1,2-dimethoxyethane at 10° C. The mixture is stirred at 50°-55° C. for 6 hours and is left at room temperature overnight. The reaction mixture is cooled in ice and is diluted with 300 ml. of ether and filtered. The solid is dissolved in 100 ml. of water and is acidified with dilute hydrochloric acid. The mixture is made basic with sodium bicarbonate and is extracted with a mixture of chloroform and methylene chloride. The combined extracts are dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The product ethyl 2-[1-benzyl-5-methyl-4-imidazolyl]-4-oxotetrahydrothiophene-5-(and/or 3)-carboxylate is obtained as a brown viscous liquid (12.6 g.).

출처