반응 #554426

반응 방정식

sodium p-toluenesulfinate

sodium p-toluenesulfinate

chloroanisole

calcium oxide

→

4'-methoxy-4-methylbiphenyl

수율 42.5%

용매

N-methyl-2-pyrrolidone

반응 조건

후처리

1. 1
   기타reacted at 150° C. in a nitrogen gas stream for 6 hours
2. 2
   기타After the completion of the reaction

실험 절차

3.56 g (20 mmol) of sodium p-toluenesulfinate, 2.85 g (20 mmol) of chloroanisole, 0.0225 g (0.1 mmol) of palladium acetate, 0.0478 g (0.12 mmol) of 1,2-bis(diphenylphosphino)-ethane, 3.37 g (60 mmol) calcium oxide and 60 ml of N-methyl-2-pyrrolidone were placed in a 100 ml round bottom flask and reacted at 150° C. in a nitrogen gas stream for 6 hours. After the completion of the reaction, the reaction mixture was analyzed by means to high performance liquid chromatography. The analysis showed that 46% of sodium p-toluenesulfinate was converted and 8.5 mmol (yield 42%) of 4'-methoxy-4-methylbiphenyl was formed in the reaction mixture solution.

출처