반응 #5543

반응 방정식

5-[2-(phenoxycarbonyloxy)ethylthio]imidazo[1,2-a]pyridine

3-aminopropanol

→

desired product

수율 55.6%

5-[2-[3-(hydroxy)propylcarbamoyloxy]ethylthio]imdazo[1,2-a]pyridine

수율 55.6%

용매

chloroform

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled
2. 2
   세척which was washed with water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   기타Then, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20)

실험 절차

To 5-[2-(phenoxycarbonyloxy)ethylthio]imidazo[1,2-a]pyridine (1.10 g, 3.50 mmoles) was added 3-aminopropanol (0.27 ml, 3.52 mmoles) and the mixture was stirred at 120° C. for 1.5 hours. The reaction mixture was cooled by standing and chloroform was added thereto, which was washed with water and dried over anhydrous magnesium sulfate, and then the solvent was distilled off. Then, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20) to obtain 575 mg of the desired product (55.6%, colorless crystals).

출처