반응 #5540

반응 방정식

5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine

phthalic anhydride

→

desired product

수율 84.8%

5-[2-[2-(carboxy)benzoylamino]ethylthio]imidazo[1,2-a]pyridine

수율 84.8%

용매

chloroform

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도at reflux for 5 hours
3. 3
   온도The reaction mixture was cooled
4. 4
   기타The crystals precipitated
5. 5
   여과were filtered off
6. 6
   세척washed with chloroform
7. 7
   기타dried

실험 절차

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.12 g, 5.8 mmoles) in chloroform (58 ml) was added phthalic anhydride (1.12 g, 7.56 mmoles) and the mixture was stirred at room temperature for 14 hours and then heated at reflux for 5 hours. The reaction mixture was cooled by standing. The crystals precipitated were filtered off, washed with chloroform and dried to obtain 1.68 g of the desired product (84.8%, colorless crystals).

출처