반응 #5538

반응 방정식

HCl

2-ethoxycarbonyl-5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

NaOH

methanol

→

desired product

수율 51.1%

2-carboxymethyl-5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

수율 51.1%

용매

methylene chloride

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   workup.DISTILLATIONthe solvent was distilled off
3. 3
   workup.ADDITIONWater was added to the residue
4. 4
   세척the resulting solid was washed with water
5. 5
   기타dried

실험 절차

To a solution of 2-ethoxycarbonyl-5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (1.65 g, 4.62 mmoles) in methanol (5 ml) was added 1N NaOH (6.93 ml, 6.93 mmoles) and the mixture was stirred at room temperature for 2.5 hours. After the reaction mixture was washed with methylene chloride, 1N HCl (17.39 ml, 17.39 mmoles) was added thereto and the solvent was distilled off. Water was added to the residue and the resulting solid was washed with water and dried to obtain 777 mg of the desired product (51.1%, colorless solid).

출처