반응 #553518

반응 방정식

2-(2-hydroxy-5-bromophenyl)-2-methyl-1,3-dioxolane

triethylamine

trimethylsilyl chloride

→

crude product

수율 100.6%

2-(2-Trimethylsilyloxy-5-bromophenyl)-2-methyl-1,3-dioxolane

수율 100.6%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.ADDITIONwas added dropwise succesively
2. 2
   여과filtered
3. 3
   농축The filtrate was concentrated under reduced pressure

실험 절차

Under ice-cooling, to a solution of 3.11 g (12 mmol) of 2-(2-hydroxy-5-bromophenyl)-2-methyl-1,3-dioxolane in 24 ml of tetrahydrofuran was added dropwise succesively, 1.84 ml (13.2 mmol) of triethylamine and 1.68 ml (13.2 mmol) of trimethylsilyl chloride with stirring. The mixture was stirred at room temperature for 2 hours and filtered. The filtrate was concentrated under reduced pressure to give 4.0 g of the crude product.

출처