반응 #5535

반응 방정식

5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine

hydrogen chloride methanol

→

desired product

수율 89.3%

5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride

수율 89.3%

용매

methanol

반응 조건

후처리

1. 1
   workup.DISTILLATIONAfter the solvent was distilled off
2. 2
   기타the residue was crystallized from chloroform ether
3. 3
   기타Then, the crystals thus obtained
4. 4
   세척were washed with ether
5. 5
   기타dried

실험 절차

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

출처