반응 #55337

반응 방정식

2-[4-(4-carboxypiperidino)butoxy]bibenzyl hydrochloride

thionyl chloride

ethanol

→

2-[4-(4-ethoxycarbonylpiperidino)butoxy]bibenzyl hydrochloride

수율 87.0%

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도under reflux for 30 minutes
3. 3
   농축concentrated in vacuo
4. 4
   기타recrystallized from ethanolether

실험 절차

To a solution of 3 g of 2-[4-(4-carboxypiperidino)butoxy]bibenzyl hydrochloride in 30 ml of ethanol was added dropwise 0.9 g of thionyl chloride. The reaction mixture was stirred for one hour, heated under reflux for 30 minutes, concentrated in vacuo and then recrystallized from ethanolether to give 2.8 g (87% yield) of 2-[4-(4-ethoxycarbonylpiperidino)butoxy]bibenzyl hydrochloride, m. p. 84°-87° C.

출처