반응 #55310

반응 방정식

1,4-dioxane

4,5-dicyanoimidazole

triethylamine

dimethylcarbamoyl chloride

→

1-(N,N-Dimethylcarbamoyl)-4,5-dicyanoimidazole

반응 조건

후처리

1. 1
   온도refluxed for 3 days
2. 2
   기타evaporated to dryness
3. 3
   workup.STIRRINGThe residue is stirred in 50 ml of ethyl acetate
4. 4
   기타The organic layer is separated
5. 5
   세척washed
6. 6
   기타dried
7. 7
   기타evaporated
8. 8
   기타to give 8 g

실험 절차

To 50 ml of dry 1,4-dioxane 6.0 g (0.05 mole) of 4,5-dicyanoimidazole, 5.0 g (0.05 mole) of triethylamine and 6.0 g (0.055 mole) of dimethylcarbamoyl chloride are added in succession at room temperature. This mixture is stirred and refluxed for 3 days, cooled to room temperature and evaporated to dryness. The residue is stirred in 50 ml of ethyl acetate and 50 ml water. The organic layer is separated, washed, dried and evaporated to give 8 g. (85%) of white product.

출처