반응 #55284

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3-carbethoxythiomorpholine

4-chlorophenyl isocyanate

→

3-carbethoxy-4-(4-chlorophenylaminocarbonyl)thiomorpholine

수율 30.5%

반응 조건

후처리

1. 1
   기타A mild exothermic reaction
2. 2
   workup.ADDITIONmixed
3. 3
   여과the precipitate was collected by filtration
4. 4
   기타recrystallized from a mixture of methylene chloride and ether

실험 절차

Seven grams of 3-carbethoxythiomorpholine and 6.5 g of 4-chlorophenyl isocyanate were added to 60 ml of hexanes containing 10 drops of triethylamine as a catalyst. A mild exothermic reaction took place as the reactants mixed. After the mixture cooled to room temperature, the precipitate was collected by filtration and recrystallized from a mixture of methylene chloride and ether to give 4 g of 3-carbethoxy-4-(4-chlorophenylaminocarbonyl)thiomorpholine, mp 152.5°-154.5° C.

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