반응 #552766

반응 방정식

ethyl acetate

t-butyl 8-(p-chlorophenylsulfonamido)-4-(3-iodopropyl)-octanoate

imidazole

→

t-butyl 8-(p-chlorophenylsulfonamido)-4-[3-(1-imidazolyl)propyl]-octanoate

용매

dimethylformamide

반응 조건

후처리

1. 1
   세척washed with water and brine
2. 2
   기타The organic layer is dried
3. 3
   여과filtered
4. 4
   농축concentrated

실험 절차

To a solution of 0.32 g (0.57 mmol) of t-butyl 8-(p-chlorophenylsulfonamido)-4-(3-iodopropyl)-octanoate in 3 ml dry dimethylformamide is added 0.116 g (1.7 mmol) imidazole and the mixture is then refluxed with ethyl acetate and washed with water and brine. The organic layer is dried, filtered, concentrated and then subjected to chromatography using ethyl acetate as eluent to yield t-butyl 8-(p-chlorophenylsulfonamido)-4-[3-(1-imidazolyl)propyl]-octanoate; IR (neat): 1718, 1337, 1164 cm-1 ; NMR (CDCl3): delta 7.5 (br,1H), 7.1 (s,1H), 6.9 (s,1H), 4.2 (t,2H).

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