반응 #55267

반응 방정식

3(R),7-dimethyl octanoic acid ethyl ester

methanol

CHCl3

→

3(R),7-dimethyl octanoic acid

수율 60.0%

용매

NaOH

반응 조건

후처리

1. 1
   기타Hydrolysis
2. 2
   기타to give 207 mg

실험 절차

Hydrolysis: 400 mg. (2 mmol) of 3(R),7-dimethyl octanoic acid ethyl ester was refluxed in 6N NaOH (1 ml.) and methanol (4 ml.) for 2 hours. It was worked up as in Example 10 to give 207 mg. (60% yield) of 3(R),7-dimethyl octanoic acid (R-(+)-dihydrocitronellic acid), [α]D25 +6.81° (c=5.039, CHCl3).

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