반응 #5523

반응 방정식

(±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

triethylamine

2,2,2-trichloroethyl chloroformate

→

1-carbamylindoline

용매

CH2Cl2

반응 조건

후처리

1. 1
   추출The CH2Cl2 solution was extracted with water and 1N HCl
2. 2
   세척The organic solution was washed with saturated NaHCO3 solution and with brine solution
3. 3
   건조The CH2Cl2 solution was dried (MgSO4)
4. 4
   농축concentrated in vacuo

실험 절차

To a solution of (±)-6-acetyl-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole (2.3 g, 7.7 mmol) and triethylamine (1.1 ml, 8 mmol) in 90 ml CH2Cl2 under N2 was added dropwise a solution of 2,2,2-trichloroethyl chloroformate. The reaction mixture was stirred at RT for 1 hr. The CH2Cl2 solution was extracted with water and 1N HCl. The organic solution was washed with saturated NaHCO3 solution and with brine solution. The CH2Cl2 solution was dried (MgSO4) and concentrated in vacuo to give 3.3 g of the 1-carbamylindoline.

출처