반응 #55209

반응 방정식

3-(2',4'-difluoro-4-biphenylyl)butyronitrile

hydrochloric acid

acetic acid

→

3-(2',4'-difluoro-4-biphenylyl)butyric acid

반응 조건

후처리

1. 1
   온도under reflux for 2 hours under nitrogen
2. 2
   기타The mixture is evaporated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in dilute NaOH
4. 4
   세척the solution is washed with ether

실험 절차

1 g. of 3-(2',4'-difluoro-4-biphenylyl)butyronitrile and 6 ml. of acetic acid and 6 ml. of concentrated hydrochloric acid are heated under reflux for 2 hours under nitrogen. The mixture is evaporated. The residue is dissolved in dilute NaOH and the solution is washed with ether and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

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