반응 #55206

반응 방정식

1 -hydroxy-3-butanone

sulfuric acid

magnesium

4-bromo-2',4'-difluorobiphenyl

→

3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol

용매

ether

ether

ether

반응 조건

후처리

1. 1
   기타obtained from 2.69 g
2. 2
   workup.STIRRINGThe mixture is stirred for two hours more

실험 절차

0.44 g. of 1 -hydroxy-3-butanone in 40 ml. of ether is added dropwise, at 20° to stirred Grignard solution obtained from 2.69 g. of 4-bromo-2',4'-difluorobiphenyl and 0.24 g. of magnesium in 100 ml. of ether. The mixture is stirred for two hours more and the resulting alcoholate is decomposed with dilute sulfuric acid. The ether phase is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.

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