반응 #551334

반응 방정식

3-methylene-androst-4-ene-19-ol-17-one

sodium borohydride

→

3-Methylene-androst-4-ene-17β,19-diol

용매

water

methanol

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   세척washed with water
3. 3
   기타the organic layer separated
4. 4
   건조dried over anhydrous sodium sulfate
5. 5
   여과filtered
6. 6
   기타evaporated
7. 7
   기타The residue was purified by thick layer chromatography over silica gel

실험 절차

To a solution of 3-methylene-androst-4-ene-19-ol-17-one in methanol was added a 2 molar excess of sodium borohydride. The mixture was stirred overnight at room temperature, diluted with water, extracted with ethyl acetate, washed with water, the organic layer separated, and dried over anhydrous sodium sulfate, filtered and evaporated. The residue was purified by thick layer chromatography over silica gel using n-hexane-ethyl acetate as a solvent.

출처