반응 #55106

반응 방정식

ethyl acetate ethanol

1,4-dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole

methyl isothiocyanate

→

N-methyl-N'-[2-((1,4-dimethyl-2-imidazolyl)methylthio)ethyl]thiourea

용매

ethanol

반응 조건

실험 절차

The reaction of 1,4-dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole (derived from the 6.2 g. dihydrobromide) with methyl isothiocyanate (1.34 g.) in ethanol (50 ml.) followed by chromatography on a column of silica gel with ethyl acetate-ethanol (9:1) as eluant gave N-methyl-N'-[2-((1,4-dimethyl-2-imidazolyl)methylthio)ethyl]thiourea (2.1 g.). (Found: C, 46.8; H, 6.9; N, 21.5; S, 24.9. C10H18N4S2 requires: C, 46.5; H, 7.0; N, 21.7; S, 24.8).

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