반응 #55095

반응 방정식

4-hydroxymethyl-5-methylimidazole hydrochloride

cysteamine hydrochloride

→

4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride

수율 184.6%

용매

acetic acid

반응 조건

후처리

1. 1
   온도under reflux for 10 hours
2. 2
   온도Following cooling to 15°-20°
3. 3
   기타the solid which crystallised
4. 4
   기타was collected
5. 5
   세척washed with isopropyl alcohol

실험 절차

(i)(a) A solution of 4-hydroxymethyl-5-methylimidazole hydrochloride (30.0 g.) and cysteamine hydrochloride (23.0 g.) in acetic acid (200 ml.) was heated under reflux for 10 hours. Following cooling to 15°-20°, the solid which crystallised was collected and washed with isopropyl alcohol to give 4-methyl-5-[(2-aminoethyl)thiomethyl]imidazole dihydrochloride (45.5 g.), m.p. 189°-192°.

출처