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N-(2,6-dimethylphenyl)-N-(1-propyl-4-piperidinyl)-2-thiopheneacetamide dihydrochloride

sodium hydrogen carbonate

→

N-(2,6-dimethylphenyl)-N-(1-propyl-4-piperidinyl)-2-thiopheneacetamide

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후처리

1. 1
   추출The free base is extracted with 1,1'-oxybisethane
2. 2
   기타The extract is dried
3. 3
   기타evaporated
4. 4
   workup.DISSOLUTIONThe oily residue is dissolved in 56 parts of hexane
5. 5
   기타the solid free base is precipitated
6. 6
   여과It is filtered off
7. 7
   기타dried

실험 절차

From an aqueous solution of 2.8 parts of N-(2,6-dimethylphenyl)-N-(1-propyl-4-piperidinyl)-2-thiopheneacetamide dihydrochloride, the free base is liberated by alkalization with sodium hydrogen carbonate solution. The free base is extracted with 1,1'-oxybisethane. The extract is dried and evaporated. The oily residue is dissolved in 56 parts of hexane and after cooling to -10° C., the solid free base is precipitated. It is filtered off and dried, yielding 1.6 parts of N-(2,6-dimethylphenyl)-N-(1-propyl-4-piperidinyl)-2-thiopheneacetamide; mp. 62.5° C.

출처