반응 #55043

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N-[1-(1-methylethyl)-4-piperidinyl]-N-phenyl-2-thiopheneacetamide (E)-2-butenedioate

sodium hydroxide

→

N-[1-(1-methylethyl)-4-piperidinyl]N-phenyl-2-thiopheneacetamide ethanedioate

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후처리

1. 1
   추출The product is extracted with trichloromethane
2. 2
   세척The extract is washed with water
3. 3
   기타dried
4. 4
   여과filtered
5. 5
   기타evaporated
6. 6
   여과The salt is filtered off
7. 7
   기타dried

실험 절차

From 6 parts of N-[1-(1-methylethyl)-4-piperidinyl]-N-phenyl-2-thiopheneacetamide (E)-2-butenedioate, the free base is liberated in the conventional manner with a diluted sodium hydroxide solution. The product is extracted with trichloromethane. The extract is washed with water, dried, filtered and evaporated. The residue is converted into the ethanedioate salt in 2-propanol. The salt is filtered off and dried, yielding 3.2 parts of N-[1-(1-methylethyl)-4-piperidinyl]N-phenyl-2-thiopheneacetamide ethanedioate; mp. 167.4° C.

출처