반응 #55030

반응 방정식

hydrogen

thiophene

ethanol

N-(4-piperidinyl)-2-pyrimidinamine

→

N-[1-(1-methylethyl)-4-piperidinyl]-2-pyrimidinamine

용매

methanol

2-propanone

반응 조건

후처리

1. 1
   여과the catalyst is filtered off
2. 2
   기타the filtrate is evaporated
3. 3
   workup.DISSOLUTIONThe residue is dissolved in trichloromethane
4. 4
   세척The solution is washed successively with a diluted sodium hydroxide solution and with water
5. 5
   기타dried
6. 6
   여과filtered
7. 7
   기타evaporated

실험 절차

To 0.5 parts of a solution of 2 parts of thiophene in 40 parts of ethanol, are added 4 parts of 2-propanone, 4.5 parts of N-(4-piperidinyl)-2-pyrimidinamine and 120 parts of methanol. The whole is hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is dissolved in trichloromethane. The solution is washed successively with a diluted sodium hydroxide solution and with water, dried, filtered and evaporated, yielding 3 parts of N-[1-(1-methylethyl)-4-piperidinyl]-2-pyrimidinamine as a residue.

출처