반응 #55019

반응 방정식

ethyl 4-[(2,6-dimethylphenyl)amino]-1-piperidinecarboxylate

pyridine

benzeneacetyl chloride

→

ethyl 4-[N-(2,6-dimethylphenyl)-N-(phenylacetyl)amino]-1-piperidinecarboxylate

용매

benzene

benzene

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   온도the whole is heated
3. 3
   온도to reflux
4. 4
   온도at reflux temperature for 3h
5. 5
   온도The reaction mixture is cooled
6. 6
   여과filtered
7. 7
   세척The benzene-phase is washed with water
8. 8
   기타After evaporation
9. 9
   기타an oily residue is obtained
10. 10
    기타on triturating in 1,1'-oxybisethane

실험 절차

to a stirred solution of 8 parts of ethyl 4-[(2,6-dimethylphenyl)amino]-1-piperidinecarboxylate in 4 parts of pyridine and 80 parts of benzene are added dropwise 7.7 parts of benzeneacetyl chloride in 40 parts of benzene. After the addition is complete, the whole is heated to reflux and stirred at reflux temperature for 3h. 45. The reaction mixture is cooled and filtered. The benzene-phase is washed with water and then with sodium hydrogen carbonate solution and with water. After evaporation, an oily residue is obtained, which solidifies on triturating in 1,1'-oxybisethane, to yield 5 parts of ethyl 4-[N-(2,6-dimethylphenyl)-N-(phenylacetyl)amino]-1-piperidinecarboxylate; mp. 106° C.

출처