반응 #54998

반응 방정식

water

2-phenyl-3-t-butyl-5-hydroxymethyloxazolidine

p-toluenesulfonylchloride

→

2-phenyl-3-t-butyl-5-p-toluenesulfonyloxymethyloxazolidine

용매

triethylamine

반응 조건

후처리

1. 1
   추출extracted with ether (2×200 ml.)
2. 2
   세척The ether solution is washed with water
3. 3
   건조dried with anhydrous magnesium sulfate
4. 4
   기타evaporated to dryness
5. 5
   기타The residue is recrystallized from hexane

실험 절차

To a solution of dl-2-phenyl-3-t-butyl-5-hydroxymethyloxazolidine (12.05 g.) in triethylamine (120 ml.) 13 is added p-toluenesulfonylchloride (14.5 g.). After 6 days at room temperature the mixture is added to water (500 ml.) and extracted with ether (2×200 ml.). The ether solution is washed with water, dried with anhydrous magnesium sulfate and evaporated to dryness. The residue is recrystallized from hexane to afford 2-phenyl-3-t-butyl-5-p-toluenesulfonyloxymethyloxazolidine.

출처