반응 #54974

ord-a79709e505384a2687bef6e5cd029a87

반응 방정식

Oc1cccc(O)c1
resorcinol
CCOC(=O)CC(C)=O
ethyl acetylacetate
CCO
ethanol
Cc1cc(=O)oc2cc(O)ccc12
4-methyl-7-hydroxy-coumarin
수율 77.0%

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

0.1 mole resorcinol and 0.1 mole ethyl acetylacetate in solution in 100 ml concentrated sulphuric acid are maintained at 5° C. for 3 hours. After recyrstallisation of the solid formed from ethanol, there are obtained 12.5 grams 4-methyl-7-hydroxy-coumarin, melting at 185° C.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04151291uspto-grants-1979_04